The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

Bioorg Med Chem Lett. 2001 Feb 12;11(3):355-7. doi: 10.1016/s0960-894x(00)00654-5.

Abstract

Peptides based upon the non-prime side residues of the NS4A-4B cleavage site of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha-ketoamide moiety in place of the scissile amide bond are potent inhibitors of this enzyme.

Publication types

  • Comparative Study

MeSH terms

  • Amides / pharmacology
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / pharmacology
  • Combinatorial Chemistry Techniques
  • Humans
  • Inhibitory Concentration 50
  • Molecular Mimicry
  • Peptides / chemical synthesis
  • Peptides / pharmacology*
  • Serine Proteinase Inhibitors / chemical synthesis*
  • Serine Proteinase Inhibitors / pharmacology
  • Structure-Activity Relationship
  • Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

  • Amides
  • Antiviral Agents
  • NS4 protein, hepatitis C virus
  • Peptides
  • Serine Proteinase Inhibitors
  • Viral Nonstructural Proteins