Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation

M R van Eerde; H H Kampinga; B G Szabo; Z Vujaskovic

doi:10.1016/s0167-8140(00)00301-7

Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation

Radiother Oncol. 2001 Mar;58(3):313-6. doi: 10.1016/s0167-8140(00)00301-7.

Authors

M R van Eerde¹, H H Kampinga, B G Szabo, Z Vujaskovic

Affiliation

¹ Department of Radiotherapy, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

PMID: 11230893
DOI: 10.1016/s0167-8140(00)00301-7

Abstract

The purpose of this study is to define differences in radiation sensitivity among rat strains using breathing frequency and lung perfusion as end points of radiation-induced lung injury. The results have confirmed previous findings in mice showing that under stringently controlled iso-dose/volume irradiation conditions, substantial differences can be found in susceptibility to functional lung damage after radiation.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Disease Susceptibility
Lung / diagnostic imaging
Lung / radiation effects*
Lung Diseases / diagnostic imaging
Lung Diseases / etiology*
Lung Diseases / physiopathology
Pulmonary Circulation / radiation effects
Radiation Dosage
Radiation Injuries* / diagnostic imaging
Radiation Injuries* / physiopathology
Radiation Tolerance
Radionuclide Imaging
Rats
Rats, Inbred F344
Rats, Inbred Strains*
Rats, Sprague-Dawley
Rats, Wistar
Respiration / radiation effects