Clear cell sarcoma of the pediatric kidney: detailed description and analysis of variant histologic patterns of a tumor with many faces

Adv Anat Pathol. 2001 Mar;8(2):98-108. doi: 10.1097/00125480-200103000-00006.

Abstract

Clear cell sarcoma of the kidney is the most frequently misdiagnosed renal tumor in children. The majority of tumors present the classic histologic pattern, which allows a definitive diagnosis. However, there are unusual cases with lack of "clear" appearance of tumor cells, predominance or exclusive presence of variant histologic patterns, and presence of "neoplastic" appearing entrapped tubules. Furthermore, a small biopsy specimen may not show the classic histologic pattern. These tumors present a diagnostic challenge for the practicing pathologist who should be aware of the deviations from the classic histologic features in order to make a correct diagnosis.

MeSH terms

  • Adolescent
  • Adult
  • Biomarkers, Tumor / analysis
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunohistochemistry
  • Infant
  • Kidney Neoplasms / chemistry
  • Kidney Neoplasms / mortality
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Sarcoma, Clear Cell / chemistry
  • Sarcoma, Clear Cell / mortality
  • Sarcoma, Clear Cell / pathology*
  • Sarcoma, Clear Cell / surgery
  • Survival Rate

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins