Abstract
Erythrocytes express the Duffy antigen receptor for chemokines. Endotoxin injection into humans induced high levels of interleukin-8 (IL-8), growth-related oncogene alpha, and monocyte chemoattractant protein 1 in circulating erythrocytes. IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Blood Cells / metabolism
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Chemokine CCL2 / biosynthesis
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Chemokine CCL4
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Chemokine CXCL1
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Chemokines / biosynthesis*
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Chemokines, CXC*
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Chemotactic Factors / biosynthesis
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Growth Substances / biosynthesis
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Humans
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Intercellular Signaling Peptides and Proteins*
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Interleukin-8 / biosynthesis
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Lipopolysaccharides / toxicity*
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Macrophage Inflammatory Proteins / biosynthesis
Substances
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CXCL1 protein, human
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Chemokine CCL2
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Chemokine CCL4
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Chemokine CXCL1
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Chemokines
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Chemokines, CXC
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Chemotactic Factors
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Interleukin-8
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Lipopolysaccharides
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Macrophage Inflammatory Proteins