Compliance with antipsychotic treatment

Acta Psychiatr Scand Suppl. 2000:(407):83-6. doi: 10.1034/j.1600-0447.2000.00016.x.

Abstract

Objective: Despite the demonstrated efficacy of antipsychotics the relapse rate among patients with schizophrenia remains high. One major reason for this is non-compliance. In this article we review different factors influencing compliance and discuss possibilities to enhance compliance among schizophrenic patients.

Method: This review is based on a systematic literature search in Medline.

Results: We summarize the four main factors (patient-, environment-, physician- and treatment-related) that influence compliance and discuss possible measures to enhance compliance. Next to many other variables discussed in more detail, it is crucial to ensure a positive doctor-patient relationship and to provide sufficient information about the benefit/risk ratio of the medication as well as about the illness itself to build up and sustain compliance. Significant others should be included into the therapeutic alliance whenever possible.

Conclusion: Despite many published reports on compliance, it remains to be a problem of eminent clinical relevance. Clinicians must not underestimate it in order to optimize the treatment of patients with schizophrenia.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance*
  • Physician-Patient Relations
  • Recurrence
  • Risk Factors
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents