Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Nat Genet. 2001 Jun;28(2):126-8. doi: 10.1038/88836.

Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chromosomes, Human, Pair 6
  • Genetics, Population
  • Humans
  • Linkage Disequilibrium*
  • Microsatellite Repeats
  • Polymorphism, Genetic
  • Proto-Oncogene Proteins / genetics*
  • Receptor, Notch4
  • Receptors, Cell Surface*
  • Receptors, Notch
  • Schizophrenia / genetics*
  • United Kingdom

Substances

  • NOTCH4 protein, human
  • Proto-Oncogene Proteins
  • Receptor, Notch4
  • Receptors, Cell Surface
  • Receptors, Notch