Abstract
A new coumarin identified as 5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one (isoobtusitin) was isolated from Psiadia dentata. This compound showed, in vitro, a moderate inhibitory activity against poliovirus and a very weak activity against (HIV), whereas it was inactive against (HSV1), (VSV), and murine tumoral cell lines (3LL, L1210).
MeSH terms
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Animals
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Poliovirus / drug effects
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Reunion
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Antiviral Agents
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Coumarins