Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics

Org Lett. 2001 Feb 8;3(3):437-40. doi: 10.1021/ol006942q.

Abstract

[figure: see text] Bogorol A (1), a novel peptide antibiotic active against MRSA and VRE, has been isolated from cultures of a marine Bacillus sp. collected in Papua New Guinea. The structure of bogorol A was elucidated by a combination of spectroscopic analyses and chemical degradation. Bogorol A illustrates a new structural template for "cationic peptide antibiotics".

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Antimicrobial Cationic Peptides
  • Bacillus / metabolism*
  • Cations
  • Enterococcus / drug effects
  • Magnetic Resonance Spectroscopy
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Peptides*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Staphylococcus aureus / drug effects
  • Templates, Genetic
  • Vancomycin Resistance

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Cations
  • Peptides
  • bogorol A