Linking class-switch recombination with somatic hypermutation

Nat Rev Mol Cell Biol. 2001 Jul;2(7):493-503. doi: 10.1038/35080033.

Abstract

The recent discovery of a molecular link between two apparently different genetic alteration events--class-switch recombination and somatic hypermutation--has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • APOBEC-1 Deaminase
  • Animals
  • Cytidine Deaminase / genetics
  • Cytidine Deaminase / metabolism*
  • DNA / metabolism
  • Genes, Reporter
  • Germinal Center / immunology
  • Immunoglobulin Class Switching / genetics*
  • Models, Genetic
  • Mutation*
  • Nucleic Acid Conformation
  • RNA Editing
  • Recombinant Fusion Proteins / metabolism
  • Recombination, Genetic*

Substances

  • Recombinant Fusion Proteins
  • DNA
  • AICDA (activation-induced cytidine deaminase)
  • APOBEC-1 Deaminase
  • Cytidine Deaminase