A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents

J Med Chem. 2001 Aug 2;44(16):2507-10. doi: 10.1021/jm015509z.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Transport System X-AG*
  • Animals
  • Aspartic Acid / chemical synthesis*
  • Aspartic Acid / chemistry
  • Aspartic Acid / metabolism
  • Biological Transport
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism
  • Cerebral Cortex / metabolism
  • Drug Design
  • Excitatory Amino Acid Transporter 3
  • Glutamate Plasma Membrane Transport Proteins
  • Glutamates / chemical synthesis*
  • Glutamates / chemistry
  • Glutamates / metabolism
  • In Vitro Techniques
  • Models, Molecular
  • Molecular Conformation
  • Neuroprotective Agents / chemical synthesis
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / metabolism
  • Patch-Clamp Techniques
  • Radioligand Assay
  • Rats
  • Sodium / metabolism*
  • Structure-Activity Relationship
  • Symporters*

Substances

  • Amino Acid Transport System X-AG
  • Carrier Proteins
  • Excitatory Amino Acid Transporter 3
  • Glutamate Plasma Membrane Transport Proteins
  • Glutamates
  • Neuroprotective Agents
  • Slc1a1 protein, rat
  • Symporters
  • Aspartic Acid
  • Sodium