Anti-inflammatory and analgesic activity of Hypericum empetrifolium Willd. (Guttiferae)

Farmaco. 2001 May-Jul;56(5-7):455-7. doi: 10.1016/s0014-827x(01)01061-8.

Abstract

A methanolic extract of Hypericum empetrifolium Willd. was evaluated for anti-inflammatory properties in rats (subplantar edema induced by carrageenan) and analgesic effects in mice (hot plate and writhing tests). Our results showed that the methanolic extract exhibits a significant anti-inflammatory activity and analgesic effects only in one of the experimental models (writhing test). Therefore, we may suppose that the methanolic extract of H. empetrifolium is active against inflammatory pain.

MeSH terms

  • Analgesics, Non-Narcotic / pharmacology*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Carrageenan
  • Edema / chemically induced
  • Edema / pathology
  • Hypericum / chemistry*
  • Injections, Intraperitoneal
  • Male
  • Methanol
  • Mice
  • Pain Measurement / drug effects
  • Plant Extracts / pharmacology
  • Rats
  • Reaction Time / drug effects

Substances

  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Carrageenan
  • Methanol