Increased RNA affinity of HNA analogues by introducing alkoxy substituents at the C-1 or C-3 position

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):781-4. doi: 10.1081/NCN-100002429.

Abstract

1,5-Anhydrohexitol nucleoside congeners with alkoxy substituents, were prepared, resulting in a further improvement of their RNA affinity and antisense potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Kinetics
  • Nucleosides / chemical synthesis*
  • Nucleosides / metabolism
  • Oligonucleotides, Antisense / chemical synthesis
  • Oligonucleotides, Antisense / metabolism
  • RNA / chemistry
  • RNA / metabolism*
  • Structure-Activity Relationship
  • Sugar Alcohols / chemical synthesis
  • Sugar Alcohols / chemistry*
  • Sugar Alcohols / metabolism

Substances

  • Nucleosides
  • Oligonucleotides, Antisense
  • Sugar Alcohols
  • RNA