Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression

J Virol. 2001 Nov;75(21):10455-9. doi: 10.1128/JVI.75.21.10455-10459.2001.

Abstract

In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / virology*
  • HIV-1 / classification
  • HIV-1 / pathogenicity*
  • Humans
  • Leukocyte Common Antigens / analysis
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Receptors, CCR5 / analysis*
  • Receptors, CXCR4 / analysis*
  • T-Lymphocyte Subsets / virology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / analysis

Substances

  • Receptors, CCR5
  • Receptors, CXCR4
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Leukocyte Common Antigens
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1