Abstract
The effects of allitridum on the proliferation of cultured rabbit aortic smooth muscle cells (SMC) were studied with SMC incorporation data of 3H-thymidine(3H-TdR) and contents of superoxide dismutase(SOD), lipid peroxide(LPO), prostacyclin(PGI2) and cyclic adenosine monophosphate(cAMP) in medium. The results showed that allitridum could inhibit SMC proliferation by increasing SOD activity, decreasing LPO, raising PGI2 and cAMP(all P < 0.05-0.01), and the inhibitory action was accompanied by the dose-effect relation.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / isolation & purification
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Allyl Compounds / pharmacology*
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Animals
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Antioxidants / pharmacology*
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Aorta / metabolism
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Cell Division / drug effects
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Cells, Cultured
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Dose-Response Relationship, Drug
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Epoprostenol / metabolism
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Garlic / chemistry
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Hypolipidemic Agents / pharmacology*
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Malondialdehyde / metabolism
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / metabolism*
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Rabbits
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Sulfides / isolation & purification
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Sulfides / pharmacology*
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Superoxide Dismutase / metabolism
Substances
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Allyl Compounds
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Antioxidants
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Hypolipidemic Agents
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Sulfides
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diallyl trisulfide
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Malondialdehyde
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Epoprostenol
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Superoxide Dismutase