Leptin and puberty

Trends Endocrinol Metab. 2001 Dec;12(10):428-9. doi: 10.1016/s1043-2760(01)00505-7.

Abstract

Leptin is thought to relay metabolic information to the hypothalamic-pituitary- gonadal axis and to participate in the neuroendocrine control of puberty. To help elucidate the underlying mechanism, Cheung et al. recently performed a diverse series of experiments, the results of which undermine the prevailing hypothesis that leptin acts as a metabolic trigger for the initiation of puberty. Instead, their results suggest that leptin is one of many permissive metabolic factors that allow pubertal development to proceed.

Publication types

  • News

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Female
  • Humans
  • Leptin / administration & dosage*
  • Leptin / blood*
  • Male
  • Mice
  • Puberty / drug effects*
  • Puberty / physiology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Rats
  • Receptors, Cell Surface*
  • Receptors, Leptin

Substances

  • Carrier Proteins
  • LEPR protein, human
  • Leptin
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, Leptin
  • leptin receptor, mouse