Abstract
In a tuberculosis (TB) program in the Central Penitentiary Hospital of Azerbaijan, we analyzed 65 isolates of Mycobacterium tuberculosis by IS6110-based restriction fragment-length polymorphism (RFLP) and spoligotyping. From 11 clusters associated with 33 patients, 31 isolates had an IS6110-based banding pattern characteristic of the Beijing genotype of M. tuberculosis. In addition, 15 M. tuberculosis isolates with similar RFLP patterns constituted a single group by spoligotyping, matching the Beijing genotype. Multidrug resistance, always involving isoniazid and rifampin, was seen in 34 (52.3%) of 65 isolates, with 28 belonging to the Beijing genotype.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antitubercular Agents / pharmacology
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Azerbaijan / epidemiology
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Bacterial Typing Techniques
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DNA Transposable Elements / genetics
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DNA-Directed RNA Polymerases / genetics
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Drug Resistance, Multiple, Bacterial
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Oligonucleotides / analysis
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Polymorphism, Restriction Fragment Length
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Prisoners*
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Tuberculosis, Multidrug-Resistant / epidemiology*
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Tuberculosis, Multidrug-Resistant / microbiology
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Tuberculosis, Multidrug-Resistant / transmission
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Tuberculosis, Pulmonary / epidemiology*
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Tuberculosis, Pulmonary / microbiology
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Tuberculosis, Pulmonary / transmission
Substances
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Antitubercular Agents
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DNA Transposable Elements
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Oligonucleotides
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit