Abstract
Background:
Midtrimester amniocentesis to investigate fetal karyotype carries a small risk of fetal loss.
Aim:
To test the hypothesis that progesterone prophylaxis may reduce this.
Study design:
A randomised controlled trial comparing a short prophylactic treatment with progesterone after amniocentesis with untreated controls.
Results:
There were no differences in frequency of miscarriage, preterm delivery or neonatal outcome.
Conclusion:
Prophylactic progesterone treatment after amniocentesis does not improve obstetric outcome.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Abortion, Spontaneous / epidemiology
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Abortion, Spontaneous / prevention & control
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Adult
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Amniocentesis / adverse effects*
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Female
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Fetal Death / epidemiology
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Fetal Death / prevention & control
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Fetal Membranes, Premature Rupture / epidemiology
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Fetal Membranes, Premature Rupture / prevention & control
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Gestational Age*
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Humans
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Obstetric Labor, Premature / epidemiology
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Obstetric Labor, Premature / prevention & control
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Pregnancy
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Pregnancy Complications / etiology
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Pregnancy Complications / prevention & control*
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Progesterone / therapeutic use*