Objective: To observe the reversive effect of Composite Bailong recipe (BR), a preparation of Chinese herbal medicine, on proliferation phenotype of human gastric carcinoma BGC82-3 cell line.
Methods: Observation was conducted by using growth curve, colony on soft agar and nude mice oncogenesis experiment.
Results: Growth curve showed the proliferation of BGC82-3 cell was obviously inhibited by BR, the inhibiting rate reached 86% in the 5th day. The colony was few and small on soft agar after treated with BR, only accounted for 52% as compared with that of nontreated. BR obviously inhibited the oncogenesis of BGC82-3 cells in nude mice, the inhibition rate being 50%.
Conclusion: Composite BR has obvious inhibiting action on malignant proliferation of human gastric BGC82-3 cell line.