Prostacyclin analogs as the brakes for pulmonary artery smooth muscle cell proliferation: is it sufficient to treat severe pulmonary hypertension?

Am J Respir Cell Mol Biol. 2002 Feb;26(2):171-4. doi: 10.1165/ajrcmb.26.2.f230.
No abstract available

Publication types

  • Comment

MeSH terms

  • Animals
  • Antihypertensive Agents / chemistry
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use
  • Cell Division / drug effects
  • Epoprostenol / analogs & derivatives*
  • Epoprostenol / chemistry
  • Epoprostenol / pharmacology
  • Epoprostenol / physiology*
  • Humans
  • Hypertension, Pulmonary / drug therapy
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / pathology
  • Hypertension, Pulmonary / physiopathology*
  • Lung / metabolism
  • Lung / pathology
  • Models, Biological
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / drug effects*
  • Muscle, Smooth, Vascular / metabolism
  • Pulmonary Artery / cytology
  • Pulmonary Artery / drug effects*
  • Pulmonary Artery / metabolism
  • Receptors, Epoprostenol
  • Receptors, Prostaglandin / metabolism
  • Signal Transduction / physiology

Substances

  • Antihypertensive Agents
  • Receptors, Epoprostenol
  • Receptors, Prostaglandin
  • Epoprostenol