Cytosines do it, thymines do it, even pseudouridines do it--base flipping by an enzyme that acts on RNA

Structure. 2002 Feb;10(2):127-9. doi: 10.1016/s0969-2126(02)00710-4.

Abstract

In the December 28, 2001 issue of Cell, Hoang and Ferré-D'Amaré report the structure of a tRNA pseudouridine synthase, showing the target uridine flipped out from the tRNA and confirming that base flipping is not limited to enzymes that act on DNA.

MeSH terms

  • Base Pairing
  • Cytosine / metabolism*
  • Intramolecular Transferases / metabolism*
  • Models, Molecular
  • Molecular Conformation
  • Nucleic Acid Conformation*
  • Pseudouridine / metabolism*
  • RNA / chemistry*
  • RNA / genetics*
  • RNA / metabolism
  • Ribosomes / chemistry
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Thymine / metabolism*

Substances

  • Pseudouridine
  • RNA
  • Cytosine
  • Intramolecular Transferases
  • tRNA-pseudouridine synthase I
  • Thymine