Towards the structure of the mammalian signal recognition particle

Curr Opin Struct Biol. 2002 Feb;12(1):72-81. doi: 10.1016/s0959-440x(02)00292-0.

Abstract

The signal recognition particle (SRP) is a ubiquitous ribonucleoprotein particle involved in the co-translational targeting of proteins to membranes. Crystal structures are now available for three protein-RNA subcomplexes from the SRP, which give insights into fundamental aspects of protein-RNA recognition, the assembly of stable ribonucleoprotein particles and the mechanism of action of the SRP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alu Elements
  • Animals
  • Base Sequence
  • Escherichia coli
  • Mammals
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Protein Conformation
  • Protein Structure, Tertiary
  • RNA / chemistry
  • RNA, Bacterial / chemistry
  • RNA-Binding Proteins / chemistry
  • Signal Recognition Particle / chemistry*
  • Signal Recognition Particle / physiology

Substances

  • RNA, Bacterial
  • RNA-Binding Proteins
  • SRP19 protein, human
  • Signal Recognition Particle
  • RNA