Eukaryotic transcription factors

Curr Opin Struct Biol. 2002 Feb;12(1):107-14. doi: 10.1016/s0959-440x(02)00296-8.

Abstract

Recently determined high-resolution structures of eukaryotic transcription factors have illuminated the enzymatic mechanism underlying transcription. Progress has been made in characterising protein-protein interactions between negative cofactors and general transcription factors, and between transrepression domains and corepressors. Structures of sequence-specific transcription factors have revealed further versatility in the mode of interaction with DNA and several have provided new insights into the molecular basis of human disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Methylation
  • Eukaryotic Cells
  • Gene Expression Regulation
  • Helix-Turn-Helix Motifs / physiology
  • Humans
  • Protein Conformation
  • Structure-Activity Relationship
  • Transcription Factor TFIID
  • Transcription Factor TFIIH
  • Transcription Factors / chemistry*
  • Transcription Factors / physiology*
  • Transcription Factors, TFII / physiology
  • Transcription, Genetic
  • Tumor Suppressor Protein p53 / chemistry
  • Tumor Suppressor Protein p53 / physiology

Substances

  • Transcription Factor TFIID
  • Transcription Factors
  • Transcription Factors, TFII
  • Tumor Suppressor Protein p53
  • Transcription Factor TFIIH