Female addicts (N= 108) with a mean age of 37.2 were tested using the Temperament and Character Inventory (TCI) in 1996-97. In a representative sub-sample (N = 49) assessed with the Structured Clinical Interview. DSMIIIr (SCID), 82% manifested an axis-1-syndrome (lifetime), and 53% a personality disorder. Of the 108 addicts, 42 preferred alcohol, 14 heroin, 33 amphetamines, and 19 benzodiazepines. Maturity was low, but there were no differences in maturity between drug preference groups. Results indicated that those less mature were more "novelty-seeking" and "harm-avoidant", while those maturer tended to be more persistent. Less mature persons answered less consistently. They agreed more with different items and their answers were more rare when compared to the general population. Heroin addicts were less sentimental and helpful and more aware of their own resources. Benzodiazepine and amphetamine addicts were more self-transcendent and self-forgetful. Among the relatively more mature, benzodiazepine addicts scored higher than heroin and alcohol addicts on "true" and rare answers. In conclusion, maturity and the drug of choice among female addicts were related to different TCI scales.