Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth

Antimicrob Agents Chemother. 2002 Apr;46(4):1153-5. doi: 10.1128/AAC.46.4.1153-1155.2002.

Abstract

The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.

MeSH terms

  • Candida albicans / genetics*
  • Candida albicans / growth & development*
  • Candida albicans / ultrastructure
  • Catheterization / adverse effects*
  • Colony Count, Microbial
  • DNA-Binding Proteins / genetics*
  • Fungal Proteins / genetics*
  • Genotype
  • Microscopy, Electron, Scanning
  • Mutation / genetics
  • Phenotype
  • Polyurethanes
  • Transcription Factors / genetics*

Substances

  • CPH1 protein, Candida albicans
  • DNA-Binding Proteins
  • EFG1 protein, Candida albicans
  • Fungal Proteins
  • Polyurethanes
  • Transcription Factors