Abstract
The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.
MeSH terms
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Candida albicans / genetics*
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Candida albicans / growth & development*
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Candida albicans / ultrastructure
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Catheterization / adverse effects*
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Colony Count, Microbial
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DNA-Binding Proteins / genetics*
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Fungal Proteins / genetics*
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Genotype
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Microscopy, Electron, Scanning
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Mutation / genetics
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Phenotype
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Polyurethanes
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Transcription Factors / genetics*
Substances
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CPH1 protein, Candida albicans
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DNA-Binding Proteins
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EFG1 protein, Candida albicans
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Fungal Proteins
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Polyurethanes
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Transcription Factors