Aim: To characterize clinicomorphological and psychosomatic manifestations of ulcer disease (UD) with reference to Helicobacter pylori (HP) contamination of gastric mucosa.
Material and methods: Out of 411 UD patients HP invasion was diagnosed in 338.
Results: Patients with UD having no HP in gastric mucosa showed clinical peculiarities related to changes in psychological and vegetative status.
Conclusion: The addition of psychopharmacological drugs to conventional antiulcer therapy promoted induction of clinicoendoscopic remission of UD within optimal time and improved quality of life in patients without HP infection in the stomach.