Biosynthesis and attachment of novel bacterial polyketide synthase starter units

Nat Prod Rep. 2002 Feb;19(1):70-99. doi: 10.1039/b003939j.

Abstract

The biosynthesis and mode of attachment of a wide range of polyketide synthase (PKS) starter units in bacteria are covered in this review. Natural, unnatural, and engineered starter units associated with type I and type II PKSs are reported. The literature through early 2001 is reviewed, and 240 references cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / metabolism*
  • Anti-Bacterial Agents
  • Bacteria / enzymology*
  • Bridged-Ring Compounds / chemistry
  • Butyrates / chemistry
  • Catalysis
  • Erythromycin / analogs & derivatives
  • Erythromycin / chemistry
  • Ivermectin / analogs & derivatives
  • Ivermectin / chemistry
  • Molecular Structure
  • Multienzyme Complexes / biosynthesis*
  • Multienzyme Complexes / metabolism
  • Peptides
  • Polyenes / chemistry
  • Polyunsaturated Alkamides
  • Propionates / chemistry
  • Rifabutin / analogs & derivatives
  • Rifabutin / chemistry
  • Rifamycins / chemistry
  • Salicylates / chemistry

Substances

  • Amino Acids
  • Anti-Bacterial Agents
  • Bridged-Ring Compounds
  • Butyrates
  • Multienzyme Complexes
  • Peptides
  • Polyenes
  • Polyunsaturated Alkamides
  • Propionates
  • Rifamycins
  • Salicylates
  • Rifabutin
  • enterocin
  • Erythromycin
  • Ivermectin
  • avermectin
  • manumycin