Circulating monocyte chemoattractant protein-1 in heart transplant recipients with cardiac allograft vasculopathy

Clin Biochem. 2002 Feb;35(1):77-9. doi: 10.1016/s0009-9120(02)00276-x.

Abstract

Objective: To evaluate serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biologic marker of cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTR).

Design and methods: Serum levels of MCP-1 were measured in 49 HTR with and without CAV.

Results: HTR exhibited significantly higher serum MCP-1 levels than controls. However, no difference was observed according to the existence of CAV.

Conclusion: Serum MCP-1 levels do not constitute a marker of the CAV occurring after heart transplantation.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood*
  • Chemokine CCL2 / blood*
  • Coronary Artery Disease / blood*
  • E-Selectin / blood
  • Endothelium, Vascular / pathology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Heart Transplantation*
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Male
  • Middle Aged
  • Myocardium / pathology
  • P-Selectin / blood
  • Transplantation, Homologous
  • Vascular Cell Adhesion Molecule-1 / blood

Substances

  • Biomarkers
  • Chemokine CCL2
  • E-Selectin
  • P-Selectin
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1