Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides

Jianxing Zhang; R Jeremy Woods; Philip B Brown; Kap Duk Lee; Robert R Kane

doi:10.1016/s0960-894x(02)00050-1

Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides

Bioorg Med Chem Lett. 2002 Mar 25;12(6):853-6. doi: 10.1016/s0960-894x(02)00050-1.

Authors

Jianxing Zhang¹, R Jeremy Woods, Philip B Brown, Kap Duk Lee, Robert R Kane

Affiliation

¹ Department of Chemistry & Biochemistry and Center for Drug Discovery, Baylor University, 76798-7348, Waco, TX, USA

PMID: 11958978
DOI: 10.1016/s0960-894x(02)00050-1

Abstract

A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to determine which constituents of the mixture were responsible for the observed tissue bonding and to facilitate study of the mechanism, we have synthesized each of the primary constituents of the mixture. Each naphthalimide synthesized has been demonstrated to photochemically crosslink proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Amides / chemistry
Animals
Connective Tissue / chemistry
Cross-Linking Reagents / chemical synthesis
Cross-Linking Reagents / chemistry
Humans
Naphthalenes / chemical synthesis*
Naphthalenes / chemistry
Photoaffinity Labels / chemical synthesis*
Photoaffinity Labels / chemistry
Photochemistry
Proteins / chemistry*
Skin / chemistry

Substances

Amides
Cross-Linking Reagents
Naphthalenes
Photoaffinity Labels
Proteins