WNT signaling and lymphocyte development

Cell. 2002 Apr:109 Suppl:S13-9. doi: 10.1016/s0092-8674(02)00709-2.

Abstract

Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Humans
  • Lymphocytes / cytology*
  • Lymphocytes / metabolism*
  • Lymphoid Enhancer-Binding Factor 1
  • Mice
  • Mice, Knockout
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction*
  • Thymus Gland / cytology
  • Thymus Gland / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • DNA-Binding Proteins
  • Lymphoid Enhancer-Binding Factor 1
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins