Sex and the single (double-strand) break

Mol Cell. 2002 Apr;9(4):700-2. doi: 10.1016/s1097-2765(02)00512-9.

Abstract

It has been known for some time that DNA double-strand breaks (DSBs) initiate homologous recombination during meiosis. Two recent studies show that the fate of a single DSB in yeast is strongly influenced by the presence of other breaks in the genome, hinting that cell-wide or chromosome-regional mechanisms control the outcome of DSB repair.

Publication types

  • Comparative Study
  • Review
  • Comment

MeSH terms

  • Chromosome Breakage*
  • Chromosomes, Fungal / genetics*
  • Chromosomes, Fungal / ultrastructure
  • Crossing Over, Genetic / genetics
  • DNA Repair*
  • DNA, Fungal / genetics
  • Endodeoxyribonucleases / physiology*
  • Esterases / physiology
  • Meiosis / genetics*
  • Mitosis / genetics
  • Proton-Translocating ATPases*
  • Recombination, Genetic*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / physiology*
  • Synaptonemal Complex / physiology

Substances

  • DNA, Fungal
  • Saccharomyces cerevisiae Proteins
  • Endodeoxyribonucleases
  • Esterases
  • meiotic recombination protein SPO11
  • Proton-Translocating ATPases
  • VMA1 protein, S cerevisiae