Abstract
Isorhamnetin and quercetin produced endothelium-independent vasodilator effects in rat aorta, rat mesenteric arteries, rat portal vein and porcine coronary arteries. The effects of the two flavonoids were similar in arteries stimulated by noradrenaline, KCl, U46619 or phorbol esters but the two flavonoids were more potent in the coronary arteries than in the aorta. At high concentrations, they also induced a positive inotropic effect in isolated rat atria. Therefore, at least part of the in vivo effects of quercetin may result from its conversion to isorhamnetin which is the main metabolite of quercetin found in plasma. The arterial, venous and coronary vasodilator effects may contribute to the protective effects of flavonoids in ischaemic heart disease observed in epidemiological studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
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Animals
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Aorta / drug effects
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Aorta / physiology
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Atrial Appendage / drug effects*
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Atrial Appendage / physiology
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Cardiovascular Agents / pharmacology*
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Dose-Response Relationship, Drug
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Flavonoids / pharmacology
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Flavonols*
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In Vitro Techniques
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Male
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Mesenteric Arteries / drug effects
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Mesenteric Arteries / physiology
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Muscle Relaxation / drug effects
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Muscle, Smooth, Vascular / drug effects*
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Muscle, Smooth, Vascular / physiology
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Norepinephrine / pharmacology
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Phorbol Esters / pharmacology
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Portal Vein / drug effects
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Portal Vein / physiology
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Potassium Chloride / pharmacology
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Quercetin / analogs & derivatives*
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Quercetin / pharmacology*
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Rats
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Rats, Wistar
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Swine
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Vasodilation / drug effects
Substances
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Cardiovascular Agents
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Flavonoids
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Flavonols
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Phorbol Esters
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3-methylquercetin
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Potassium Chloride
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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Quercetin
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Norepinephrine