Palladium-catalyzed multiple arylation of thiophenes

Toru Okazawa; Tetsuya Satoh; Masahiro Miura; Masakatsu Nomura

doi:10.1021/ja0259279

Palladium-catalyzed multiple arylation of thiophenes

J Am Chem Soc. 2002 May 15;124(19):5286-7. doi: 10.1021/ja0259279.

Authors

Toru Okazawa¹, Tetsuya Satoh, Masahiro Miura, Masakatsu Nomura

Affiliation

¹ Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

PMID: 11996567
DOI: 10.1021/ja0259279

Abstract

Secondary 2-thiophenecarboxamides efficiently undergo unique triarylation accompanied by formal decarbamoylation under palladium catalysis. 3-Substituted thiophenes, especially having an electron-withdrawing group, can also be triarylated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Palladium / chemistry*
Polycyclic Aromatic Hydrocarbons / chemical synthesis*
Thiophenes / chemical synthesis
Thiophenes / chemistry*

Substances

Polycyclic Aromatic Hydrocarbons
Thiophenes
Palladium