Abstract
The ocular effects of latanoprost ophthalmic solution were evaluated in two studies, with eight horses in each study. One eye of each horse was treated with latanoprost ophthalmic solution once daily for 5 days, and the opposite eye received a control solution of sterile eyewash. Intraocular pressure and pupillary diameter were measured daily for 5 days after treatment. Latanoprost had no significant effect on intraocular pressure or pupillary diameter in normal horse eyes compared with control eyes in these studies. Placement of an eyelid nerve block resulted in significantly lower intraocular pressure.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / pharmacology*
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Antihypertensive Agents / therapeutic use
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Female
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Glaucoma / prevention & control
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Glaucoma / veterinary
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Horse Diseases / prevention & control
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Horses / physiology*
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Intraocular Pressure / drug effects*
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Latanoprost
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Male
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Ophthalmic Solutions / administration & dosage
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Ophthalmic Solutions / pharmacology
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Ophthalmic Solutions / therapeutic use
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Prostaglandins F, Synthetic / administration & dosage
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Prostaglandins F, Synthetic / pharmacology*
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Prostaglandins F, Synthetic / therapeutic use
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Pupil / drug effects
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Reference Values
Substances
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Antihypertensive Agents
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Ophthalmic Solutions
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Prostaglandins F, Synthetic
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Latanoprost