Phylogenetic analysis of spotted fever group Rickettsiae isolated from ticks in Japan

Microbiol Immunol. 2002;46(4):241-7. doi: 10.1111/j.1348-0421.2002.tb02692.x.

Abstract

Eight spotted fever group (SFG) rickettsiae isolated from ticks in Japan were classified by phylogenetic analysis based on the nucleotide sequences of both the citrate synthase-encoding gene (gltA) and 190-kDa antigen-encoding gene (rOmpA). In the phylogenetic tree of gltA, strains DT-1 and FLA-1 isolated from the Dermacentor taiwanensis and Haemaphysalis frava ticks, respectively, were placed as Rickettsia japonica, and strains IO-1, IO-2, IO-25, IM-1 and IP-2 from genus Ixodes ticks were placed as Rickettsia helvetica. Strain AT-1 isolated from the Amblyomma testudinarium belonged to the cluster including Rickettsia akari, Rickettsia australis and Rickettsia felis. In the phylogenetic tree of the rOmpA, strains DT-1 and FLA-1 were placed as R. japonica, and strain AT-1 belonged to the cluster including Rickettsia cooleyi and the symbiont of Ixodes scapularis. The rOmpA fragments of 5 Ixodes isolates could not be amplified by PCR. The present study showed that strains DT-1 and FLA-1 were genotypically identical to R. japonica, and 5 Ixodes isolates were associated with the R. helvetica. Based on previous genotypic and antigenic data, and the phylogenetic analysis presented here, strain AT-1 should be considered as a new species among SFG rickettsiae.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Proteins / genetics*
  • Citrate (si)-Synthase / genetics
  • Dog Diseases / microbiology
  • Dogs
  • Japan
  • Molecular Sequence Data
  • Phylogeny
  • Rickettsia / classification*
  • Rickettsia / genetics
  • Rickettsia / isolation & purification*
  • Sequence Homology, Amino Acid
  • Ticks / classification
  • Ticks / microbiology*

Substances

  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • rOmpA, Rickettsia
  • Citrate (si)-Synthase