Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins

Cell Mol Biol Lett. 2002;7(2):317-21.

Abstract

This review describes the ionic mechanisms involved in the nodal swelling of frog myelinated axons caused by specific marine neurotoxins (ciguatoxins, brevetoxins, Conus consors toxin and equinatoxin-II), analysed using confocal laser scanning microscopy. We have focussed on toxins that either target neuronal voltage-dependent Na+ channels, or that form cation-selective pores and indirectly affect the functioning of the Na(+)-Ca(++)exchanger.

Publication types

  • Lecture
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / drug effects*
  • Axons / physiology
  • Cations
  • Ciguatoxins / pharmacology*
  • Cnidarian Venoms / pharmacology*
  • Humans
  • Ions
  • Marine Toxins / pharmacology*
  • Neurotoxins / pharmacology*
  • Oxocins*
  • Ranvier's Nodes / drug effects*
  • Ranvier's Nodes / physiology
  • Sodium Channels / physiology

Substances

  • Cations
  • Cnidarian Venoms
  • Ions
  • Marine Toxins
  • Neurotoxins
  • Oxocins
  • Sodium Channels
  • Ciguatoxins
  • equinatoxin
  • brevetoxin