Abstract
To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA, Viral / blood*
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Epstein-Barr Virus Infections / blood
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / virology*
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HIV Infections / blood
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HIV Infections / complications
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HIV Infections / virology*
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HIV-1 / growth & development*
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Herpesvirus 4, Human / genetics*
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Herpesvirus 4, Human / growth & development
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Humans
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Leukocytes, Mononuclear / virology
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Longitudinal Studies
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Lymphoma, AIDS-Related / blood
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Lymphoma, AIDS-Related / virology*
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Lymphoma, Non-Hodgkin / blood
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Lymphoma, Non-Hodgkin / virology*
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Male
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Polymerase Chain Reaction
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Predictive Value of Tests
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Viral Load