Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1

Yong Tian; Guido J Breedveld; Shangzhi Huang; Ben A Oostra; Peter Heutink; Wilson H Y Lo

doi:10.1016/s0167-4781(02)00397-4

Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1

Biochim Biophys Acta. 2002 Aug 19;1577(1):121-5. doi: 10.1016/s0167-4781(02)00397-4.

Authors

Yong Tian¹, Guido J Breedveld, Shangzhi Huang, Ben A Oostra, Peter Heutink, Wilson H Y Lo

Affiliation

¹ Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

PMID: 12151103
DOI: 10.1016/s0167-4781(02)00397-4

Abstract

ZNF333 is a novel human KRAB-zinc finger protein gene on chromosome 19p13.1 encompassing 14 exons. ZNF333 is highly expressed in heart and encodes a 665 amino acid protein that contains a rare combination of double KRAB-domains, each consisting of a classical KRAB-A and a highly divergent KRAB-B box at the N-terminus. ZNF333 further contains 10 C2H2 zinc finger motifs at the C-terminus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Carrier Proteins / biosynthesis
Carrier Proteins / chemistry*
Carrier Proteins / genetics*
Chromosomes, Human, Pair 19*
Exons
Humans
Introns
Kruppel-Like Transcription Factors
Molecular Sequence Data
Protein Structure, Tertiary
RNA, Messenger / biosynthesis
Sequence Alignment
Tissue Distribution
Transcription Factors / biosynthesis
Transcription Factors / chemistry*
Transcription Factors / genetics*
Zinc Fingers

Substances

Carrier Proteins
Kruppel-Like Transcription Factors
RNA, Messenger
Transcription Factors
ZNF333 protein, human

Associated data

GENBANK/AF372702