Diagnostic ultrasonography of musculoskeletal diseases in the United States has been used most often for detection of rotator cuff tears or developmental dysplasia of the hip. Diagnostic ultrasonography also is useful in imaging the periarticular soft tissues about the knee, hip, ankle, occult pediatric fractures, muscle injury, bone healing, and foreign bodies. Recent technologic improvements have made this imaging modality increasingly more accurate while providing significant benefits over traditional modalities such as magnetic resonance imaging, particularly regarding cost, patient satisfaction, and ease of usage. Increasing use in the future of diagnostic ultrasonography for musculoskeletal conditions is likely as acceptance grows. This review focuses on recent, practical applications of diagnostic ultrasonography of the musculoskeletal system.