Abstract
The treatment of mixed cryoglobulinemia concurrent with HCV infection is still under debate. We report the case of a patient referred to our unit for a membranoproliferative glomerulonephritis associated with HCV infection. A nephrotic syndrome and a slight reduction of glomerular filtration rate were present. We treated him with alpha-interferon for six months and prednisone for two months. We achieved a remission of the nephrotic syndrome without any significant reduction of the viral load. One year after the therapy had been suspended, the nephrotic syndrome relapsed and subsequently responded to a combined treatment with interferon ribavirin and prednisone. HCV-RNA became suddenly and persistently negative.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Antiviral Agents / administration & dosage
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Antiviral Agents / therapeutic use*
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Cryoglobulinemia / drug therapy*
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Cryoglobulinemia / etiology
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Drug Therapy, Combination
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Glomerulonephritis, Membranoproliferative / drug therapy*
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Glomerulonephritis, Membranoproliferative / etiology
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Hepacivirus / isolation & purification
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Hepatitis C, Chronic / complications
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Hepatitis C, Chronic / drug therapy*
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Humans
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Interferon-alpha / administration & dosage
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Interferon-alpha / therapeutic use*
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Male
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Nephrotic Syndrome / drug therapy
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Nephrotic Syndrome / etiology
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Prednisone / administration & dosage
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Prednisone / therapeutic use*
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RNA, Viral / blood
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Recurrence
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Remission Induction
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Ribavirin / administration & dosage
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Ribavirin / therapeutic use*
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Viral Load
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Viremia / drug therapy
Substances
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Antiviral Agents
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Interferon-alpha
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RNA, Viral
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Ribavirin
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Prednisone