The Spiegelberg automated compliance device offers practical benefits over the standard manual injection techniques for assessing volume-pressure status. Currently, however, the system relies on the insertion of an intraventricular catheter. If automated continuous measurement of intraparenchymal compliance could be achieved, then this would be a further practical advance. Automated measurements of compliance using a prototype intraparenchymal probe were assessed in comparison with the current intraventricular probe in a sheep model of diffusely raised ICP. The results show poor correlation between intraventricular compliance (IVC) and intraparenchymal compliance (IPC) at low levels of cerebral perfusion pressure (CPP). The IPC response to decreasing CPP beyond probable levels of blood flow autoregulation suggest that IPC is more dependent on local tissue perfusion factors, rather than overall physical compliance. Further evaluation of compliance in the intraparenchymal compartment versus intraventricular compliance will be needed before adaptation of the automated system for clinical application.