[Polymorphism of the theta1 and mu1 glutathione s-transferase genes (GSTT1, GSTM1) in patients with atopic bronchial asthma from the West Siberian region]

M B Freĭdin; E Iu Bragina; L M Ogorodova; V P Puzyrev

[Polymorphism of the theta1 and mu1 glutathione s-transferase genes (GSTT1, GSTM1) in patients with atopic bronchial asthma from the West Siberian region]

Mol Biol (Mosk). 2002 Jul-Aug;36(4):630-4.

[Article in Russian]

Authors

M B Freĭdin¹, E Iu Bragina, L M Ogorodova, V P Puzyrev

Affiliation

¹ Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, 634050 Russia.

PMID: 12173466

Abstract

Polymorphism for the GSTT1 and GSTM1 null alleles was analyzed in 69 patients with atopic bronchial asthma (BA) and in 57 healthy individuals from Tomsk. The two samples did not differ in frequencies of genotypes 0/0 and + of either gene or in frequencies of genotype combinations. No association was observed for GST and BA severity. Thus, the GST null alleles proved to be unimportant for BA.

Publication types

English Abstract

MeSH terms

Asthma / genetics*
Glutathione Transferase / genetics*
Heterozygote
Humans
Polymorphism, Genetic*
Reference Values
Siberia

Substances

glutathione S-transferase T1
Glutathione Transferase