Naturally occurring cembranes from an Australian sarcophyton species

J Nat Prod. 2002 Aug;65(8):1147-50. doi: 10.1021/np010521f.

Abstract

Naturally occurring cembranes 1-4 have been isolated from a Sarcophyton sp. These compounds have not previously been found to occur in nature but had been obtained as intermediates in a synthetic modification from tobacco. The absolute stereochemistries of 3 and 4 were determined. Compounds 1 and 2 inhibited the binding of [(3)H]8-cyclopentyl-1,3-dipropylxanthine to rat-brain adenosine A(1) receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Australia
  • Brain / drug effects
  • Chromatography, High Pressure Liquid
  • Cnidaria / chemistry*
  • Cyclization
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Inhibitory Concentration 50
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rats
  • Receptors, Purinergic P1 / drug effects
  • Stereoisomerism
  • Xanthines / pharmacology

Substances

  • 11,12-epoxy-2,6-cembrane-4,8-diol
  • Diterpenes
  • Receptors, Purinergic P1
  • Xanthines
  • cembrane
  • 1,3-dipropyl-8-cyclopentylxanthine