Abstract
(1)H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p < 0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p < 0.02) and creatine-phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / analysis
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Aspartic Acid / metabolism
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Choline / analysis
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Choline / metabolism
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Creatine / analysis
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Creatine / metabolism
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Epilepsy, Temporal Lobe / surgery*
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Female
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Functional Laterality
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Hippocampus / metabolism*
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Humans
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Magnetic Resonance Spectroscopy*
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Male
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Middle Aged
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Neurosurgical Procedures*
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Phosphocreatine / analysis
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Phosphocreatine / metabolism
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Protons
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Recovery of Function*
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Reference Values
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Treatment Outcome
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Water / analysis
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Water / metabolism
Substances
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Protons
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Phosphocreatine
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Water
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Aspartic Acid
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N-acetylaspartate
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Creatine
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Choline