The interplay of dendritic cell subsets in systemic lupus erythematosus

Immunol Cell Biol. 2002 Oct;80(5):484-8. doi: 10.1046/j.1440-1711.2002.01112.x.

Abstract

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

Publication types

  • Review

MeSH terms

  • Autoantibodies / biosynthesis
  • Autoimmune Diseases / immunology*
  • B-Lymphocyte Subsets / immunology
  • CD11c Antigen / analysis
  • Cytokines / physiology
  • Dendritic Cells / classification
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Homeostasis
  • Humans
  • Interferon-alpha / physiology
  • Lupus Erythematosus, Systemic / immunology*
  • Models, Immunological
  • Myeloid Cells / immunology
  • T-Lymphocyte Subsets / immunology

Substances

  • Autoantibodies
  • CD11c Antigen
  • Cytokines
  • Interferon-alpha