Inducible AmpC beta-lactamase of a new member Enterobacteriaceae

Antimicrob Agents Chemother. 2002 Oct;46(10):3316-9. doi: 10.1128/AAC.46.10.3316-3319.2002.

Abstract

Extensive biochemical testing and 16S rRNA and rpoB sequence analysis revealed that clinical strain CF01Ent1, initially identified as Buttiauxella agrestis by the use of Api 32 biochemical strips, is a new organism in the Enterobacteriaceae family. It produced an inducible AmpC-type beta-lactamase whose sequence shares 69 to 72% identity with those of the other AmpC-type beta-lactamases of ENTEROBACTERIACEAE: This enzyme exhibits an atypical high affinity for all beta-lactams tested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Base Sequence
  • DNA-Directed RNA Polymerases / genetics
  • Enterobacteriaceae / classification*
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics
  • Enzyme Induction
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • beta-Lactam Resistance
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / chemistry
  • beta-Lactamases / genetics
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • RNA, Ribosomal, 16S
  • beta-Lactams
  • AmpR protein, Bacteria
  • DNA-Directed RNA Polymerases
  • RNA polymerase beta subunit
  • AmpC beta-lactamases
  • beta-Lactamases

Associated data

  • GENBANK/AF440406
  • GENBANK/AJ489826
  • GENBANK/AJ489827