Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis

Dev Cell. 2002 Sep;3(3):302-4. doi: 10.1016/s1534-5807(02)00231-9.

Abstract

The maturation of the vascular system and the adjustment of blood vessel density in tissues require the opposing processes of vessel growth and regression. A new study in this issue of Developmental Cell shows that Angiopoietin-2 (Ang2), a ligand for the endothelial Tie2 receptor tyrosine kinase, has a dual function in the processes of postnatal angiogenesis and vascular remodeling. Also, Ang2 signals are required for the proper development and function of the lymphatic vessels.

Publication types

  • Comment

MeSH terms

  • Angiogenesis Inducing Agents / physiology*
  • Angiopoietin-2
  • Animals
  • Blood Vessels / growth & development*
  • Blood Vessels / metabolism
  • Embryo, Mammalian / metabolism
  • Endothelial Growth Factors / genetics
  • Endothelial Growth Factors / metabolism
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Lymphatic System / growth & development*
  • Lymphatic System / metabolism
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Neovascularization, Physiologic*
  • Platelet-Derived Growth Factor / metabolism
  • Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction

Substances

  • Angiogenesis Inducing Agents
  • Angiopoietin-2
  • Endothelial Growth Factors
  • Platelet-Derived Growth Factor
  • Receptor Protein-Tyrosine Kinases