Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient

M Ihara; N Kohara; F Urano; H Ichinose; S Takao; T Nishida; H Saiki; Y Kawamoto; A Ikeda; S Takagi; H Shibasaki

doi:10.1212/wnl.59.7.1102

Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient

Neurology. 2002 Oct 8;59(7):1102-4. doi: 10.1212/wnl.59.7.1102.

Authors

M Ihara¹, N Kohara, F Urano, H Ichinose, S Takao, T Nishida, H Saiki, Y Kawamoto, A Ikeda, S Takagi, H Shibasaki

Affiliation

¹ Department of Neurology, Kyoto University Graduate School of Medicine, Japan. ihara@kuhp.kyoto-u.ac.jp

PMID: 12370475
DOI: 10.1212/wnl.59.7.1102

Abstract

The authors describe a patient with dopa-responsive dystonia who developed neuroleptic malignant syndrome with prolonged catatonia following treatment with neuroleptic agents. Use of these agents probably expanded the patient's neuronal dysfunction beyond the nigrostriatal system to involve multiple dopaminergic systems. Electroconvulsive treatment alleviated the prolonged catatonia.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Catatonia / diagnosis
Catatonia / physiopathology*
Catatonia / therapy
Dystonia / drug therapy*
Dystonia / enzymology
Dystonia / genetics
Electroencephalography / drug effects
Electroencephalography / statistics & numerical data
Female
GTP Cyclohydrolase / genetics
Humans
Levodopa / therapeutic use*
Neuroleptic Malignant Syndrome / diagnosis
Neuroleptic Malignant Syndrome / physiopathology*
Neuroleptic Malignant Syndrome / therapy

Substances

Levodopa
GTP Cyclohydrolase