Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives

Farmaco. 2002 Sep;57(9):747-51. doi: 10.1016/s0014-827x(02)01268-5.

Abstract

Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / toxicity
  • Cell Survival / drug effects
  • HIV-1 / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Structure-Activity Relationship
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / pharmacology
  • Thiadiazoles / toxicity
  • Tumor Cells, Cultured
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Thiadiazoles