We study the Q2 dependence of large x F2 nucleon structure function data, with the aim of providing a perturbative QCD based, quantitative analysis of parton-hadron duality. As opposed to previous analyses at fixed x, we use a framework in fixed W2. We uncover a breakdown of the twist-4 approximation with a renormalon type improvement at O(1/Q(4)) which affects the initial evolution of parton distributions.