Role of genetic polymorphisms in tumour angiogenesis

Br J Cancer. 2002 Nov 4;87(10):1057-65. doi: 10.1038/sj.bjc.6600625.

Abstract

Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytokines / genetics
  • Endothelial Growth Factors / genetics
  • Hepatocyte Growth Factor / genetics
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Lymphokines / genetics
  • Matrix Metalloproteinases / genetics
  • Neoplasms / blood supply*
  • Neoplasms / genetics
  • Neovascularization, Pathologic / genetics*
  • Polymorphism, Genetic*
  • Receptors, Fibroblast Growth Factor / genetics
  • Transforming Growth Factor beta / genetics
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Cytokines
  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Receptors, Fibroblast Growth Factor
  • Transforming Growth Factor beta
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Hepatocyte Growth Factor
  • Matrix Metalloproteinases